Handbook of Therapeutic Antibodies Book

Handbook of Therapeutic Antibodies


  • Author : Stefan Dübel
  • Publisher : John Wiley & Sons
  • Release Date : 2014-12-03
  • Genre: Science
  • Pages : 2544
  • ISBN 10 : 9783527329373

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Handbook of Therapeutic Antibodies Excerpt :

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial phases, as well as their potential. Volume III features detailed and specific information about each antibody currently approved for therapeutic purposes, including the clinical data. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Therapeutic Antibody Engineering Book

Therapeutic Antibody Engineering


  • Author : William R Strohl
  • Publisher : Elsevier
  • Release Date : 2012-10-16
  • Genre: Science
  • Pages : 696
  • ISBN 10 : 9781908818096

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Therapeutic Antibody Engineering Excerpt :

The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

Therapeutic Monoclonal Antibodies Book

Therapeutic Monoclonal Antibodies


  • Author : Zhiqiang An
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-20
  • Genre: Science
  • Pages : 896
  • ISBN 10 : 9781118210260

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Therapeutic Monoclonal Antibodies Excerpt :

70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.

Is the Recent Burst of Therapeutic Anti Tumor Antibodies the Tip of an Iceberg  Book

Is the Recent Burst of Therapeutic Anti Tumor Antibodies the Tip of an Iceberg


  • Author : Leonor Kremer
  • Publisher : Frontiers Media SA
  • Release Date : 2018-03-27
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889454624

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Is the Recent Burst of Therapeutic Anti Tumor Antibodies the Tip of an Iceberg Excerpt :

The high effectiveness of antibodies as anti-tumor therapeutic agents has led to a burst of research aiming to increase their therapeutic applications by the use of antibodies against new targets, new antibody formats or new combinations. In this e-book we present relevant research depicting the current efforts in the field.

Approaches to the Purification  Analysis and Characterization of Antibody Based Therapeutics Book

Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics


  • Author : Allan Matte
  • Publisher : Elsevier
  • Release Date : 2020-09-07
  • Genre: Business & Economics
  • Pages : 222
  • ISBN 10 : 9780081030196

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Approaches to the Purification Analysis and Characterization of Antibody Based Therapeutics Excerpt :

Approaches to the Purification, Analysis and Characterization of Antibody-Based Therapeutics provides the interested and informed reader with an overview of current approaches, strategies and considerations relating to the purification, analytics and characterization of therapeutic antibodies and related molecules. While there are obviously other books published in and around this subject area, they seem to be either older (c.a. year 2000 publication date) or are more limited in scope. The book will include an extensive bibliography of the published literature in the respective areas covered. It is not, however, intended to be a how-to methods book. Covers the vital new area of R&D on therapeutic antibodies Written by leading scientists and researchers Up-to-date coverage and includes a detailed bibliography

Biosimilars of Monoclonal Antibodies Book

Biosimilars of Monoclonal Antibodies


  • Author : Cheng Liu
  • Publisher : John Wiley & Sons
  • Release Date : 2016-12-12
  • Genre: Medical
  • Pages : 704
  • ISBN 10 : 9781118940631

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Biosimilars of Monoclonal Antibodies Excerpt :

Addressing a significant need by describing the science and process involved to develop biosimilars of monoclonal antibody (mAb) drugs, this book covers all aspects of biosimilar development: preclinical, clinical, regulatory, manufacturing. • Guides readers through the complex landscape involved with developing biosimilar versions of monoclonal antibody (mAb) drugs • Features flow charts, tables, and figures that clearly illustrate processes and makes the book comprehensible and accessible • Includes a review of FDA-approved mAb drugs as a quick reference to facts and useful information • Examines new technologies and strategies for improving biosimilar mAbs

Monoclonal Antibody Production Book

Monoclonal Antibody Production


  • Author : National Research Council
  • Publisher : National Academies Press
  • Release Date : 1999-06-06
  • Genre: Medical
  • Pages : 74
  • ISBN 10 : 9780309064477

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Monoclonal Antibody Production Excerpt :

The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.

Therapeutic Antibodies Book

Therapeutic Antibodies


  • Author : Gunnar Houen
  • Publisher : Humana
  • Release Date : 2021-07-28
  • Genre: Science
  • Pages : 347
  • ISBN 10 : 1071614495

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Therapeutic Antibodies Excerpt :

This detailed book covers methods for studying, producing, and analyzing therapeutic antibodies, measuring their concentration, developing neutralizing antibodies for them, and for predicting and monitoring their therapeutic efficacy and clinical effects. These biologics are the fastest growing pharmaceutical drug group and have had tremendous clinical and scientific impact in cancer, autoimmune diseases, infectious diseases, and other immune-related diseases, making the content of this volume essential. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible methods, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Therapeutic Antibodies: Methods and Protocols serves as an ideal guide for researchers working with the production of, research on, and development of therapeutic antibodies as well as for clinicians using therapeutic antibodies in daily work with patients.

Recombinant Antibodies for Immunotherapy Book

Recombinant Antibodies for Immunotherapy


  • Author : Melvyn Little
  • Publisher : Cambridge University Press
  • Release Date : 2009-07-27
  • Genre: Medical
  • Pages : 419
  • ISBN 10 : 9780521887328

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Recombinant Antibodies for Immunotherapy Excerpt :

This book provides a comprehensive overview of the field of monoclonal antibodies through twenty-five articles by recognized experts in the field.

Antibody Drug Discovery Book

Antibody Drug Discovery


  • Author : Clive R. Wood
  • Publisher : World Scientific
  • Release Date : 2012
  • Genre: Medical
  • Pages : 473
  • ISBN 10 : 9781848166288

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Antibody Drug Discovery Excerpt :

Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.

Drug Induced Liver Injury Book

Drug Induced Liver Injury


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-07-13
  • Genre: Medical
  • Pages : 288
  • ISBN 10 : 9780128173176

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Drug Induced Liver Injury Excerpt :

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Therapeutic Antibodies Book

Therapeutic Antibodies


  • Author : John Landon
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-06
  • Genre: Medical
  • Pages : 231
  • ISBN 10 : 9781447119371

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Therapeutic Antibodies Excerpt :

Several aspects of clinical medicine are poised on the edge of a new era with the introduction of therapeutic antibodies. This revolution has been made possible by major advances in immune technology, which are now beginning to mature into clinical practice. This volume is aimed at all clinicians involved with this form of treatment, especially accident and emergency physicians, clinical immunologists, and pharmacologists. It covers both the basic technology, and also all the main clinical areas of application: septic shock, auto-immune disease, and cancer. The future of therapeutic antibodies is also discussed, including exciting new developments in "catalytic antibodies". This is the first occasion on which all these topics have been brought together in a single volume, thus making it an important reference source for physicians and researchers in this fast-moving area.

Handbook of Therapeutic Antibodies Book

Handbook of Therapeutic Antibodies


  • Author : Stefan Dübel
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-04
  • Genre: Science
  • Pages : 2544
  • ISBN 10 : 9783527682447

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Handbook of Therapeutic Antibodies Excerpt :

Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume 1 covers selection and engineering strategies for new antibodies, while the second volume presents novel therapeutic concepts and antibodies in clinical study, as well as their potential. Volumes 3 and 4 feature detailed and specific information about each antibody approved for therapeutic purposes, including clinical data. This unique handbook concludes with a compendium of marketed monoclonal antibodies and an extensive index. Beyond providing current knowledge, the authors discuss emerging technologies, future developments, and intellectual property issues, such that this handbook meets the needs of academic researchers, decision makers in industry and healthcare professionals in the clinic.

Diagnostic and Therapeutic Antibodies Book

Diagnostic and Therapeutic Antibodies


  • Author : Andrew J. T. George
  • Publisher : Springer Science & Business Media
  • Release Date : 2000
  • Genre: Medical
  • Pages : 477
  • ISBN 10 : 9781592590766

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Diagnostic and Therapeutic Antibodies Excerpt :

Monoclonal Antibodies Book

Monoclonal Antibodies


  • Author : Harleen Kaur
  • Publisher : Elsevier
  • Release Date : 2021-08-03
  • Genre: Medical
  • Pages : 258
  • ISBN 10 : 9780128223192

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Monoclonal Antibodies Excerpt :

Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization. Describes the spectrum of analytical tests and characterization methods necessary for developing and releasing mAb batches Details antibody heterogeneity in terms of size, charge, and carbohydrate content Gives special focus to the structural analysis of mAbs, including mass spectrometry analysis Presents the basic structure of mAbs with clarity and rigor Addresses regulatory guidelines - including ICH Q6B - in relation to quality attributes Lays out characterization and development case studies including biosimila