Therapeutic Drug Monitoring Book

Therapeutic Drug Monitoring


  • Author : Amitava Dasgupta
  • Publisher : Academic Press
  • Release Date : 2012-06-07
  • Genre: Medical
  • Pages : 468
  • ISBN 10 : 9780123854681

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Therapeutic Drug Monitoring Excerpt :

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Therapeutic Drug Monitoring Data Book

Therapeutic Drug Monitoring Data


  • Author : Amitava Dasgupta
  • Publisher : Academic Press
  • Release Date : 2019-09-14
  • Genre: Science
  • Pages : 382
  • ISBN 10 : 9780128158500

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Therapeutic Drug Monitoring Data Excerpt :

Therapeutic Drug Monitoring Data: A Concise Guide, Fourth Edition serves as a ready resource of information on commonly monitored drugs that will help readers make decisions relating to the monitoring and interpretation of results. It is an easy-to-read source of information on intended use, pharmacokinetics, therapeutic range, and toxic concentrations, as well as bioavailability, disposition, metabolism and the excretion of commonly monitored therapeutic drugs. This fully updated fourth edition includes sections on new anticonvulsants, anti-depressant and anti-HIV drugs, new drugs for advanced cancer treatment, and thoroughly updated chapters that address new pitfalls and problems in the lab. Serves as a ready resource of information for commonly monitored drugs Presents a useful, quick guide for those making decisions related to monitoring and interpretation of results Provides concise, easily digestible content for clinical laboratory scientists, toxicologists and clinicians

Clinical Challenges in Therapeutic Drug Monitoring Book

Clinical Challenges in Therapeutic Drug Monitoring


  • Author : William Clarke
  • Publisher : Elsevier
  • Release Date : 2016-07-21
  • Genre: Medical
  • Pages : 376
  • ISBN 10 : 9780128020524

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Clinical Challenges in Therapeutic Drug Monitoring Excerpt :

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring. This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations. Offers busy clinicians, pathologists, and trainees a concise resource on the key aspects and critical issues in therapeutic drug monitoring Focuses on patient populations such as infants and children, pregnant women, elderly patients, and obese patients, who have special requirements in therapeutic drug monitoring Explores special topics in therapeutic drug monitoring including free drug monitoring and common immunoassay interference Explains how individual dosage adjustments can prevent drug toxicity for certain drugs within a narrow therapeutic window

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics Book

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics


  • Author : Georg Hempel
  • Publisher : Elsevier
  • Release Date : 2019-10-17
  • Genre: Science
  • Pages : 380
  • ISBN 10 : 9780444640673

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Methods of Therapeutic Drug Monitoring Including Pharmacogenetics Excerpt :

Methods of Therapeutic Drug Monitoring Including Pharmacogenetics, Second Edition, Volume Seven in the Handbook of Analytical Separations series, covers all aspects of drug monitoring, including laboratory work, pharmacokinetic analysis and clinical aspects, thus enabling readers from different fields to understand the whole process of therapeutic drug monitoring and how to avoid common pitfalls. The book contains analytical techniques for the quantification of drugs, along with pharmacogenetic and pharmacogenomic methods. Also included are updates on sample preparation, including dried blood spot technology and microextraction methods. In addition, the book includes new drugs, such as tyrosine kinase inhibitors and the monitoring of immunosuppressant drugs. Presents a unique, interdisciplinary approach that appeals to a wide range of users Written by authors from international labs, providing a global perspective that can be applied in various regulatory environments Features additional therapeutic drugs to reflect the rising number of immunocompromised patients Includes a new mass spectroscopic methods chapter to capture the frequent use in TDM and the improved availability of LC-MS across laboratories

Analytical Methods for Therapeutic Drug Monitoring and Toxicology Book

Analytical Methods for Therapeutic Drug Monitoring and Toxicology


  • Author : Q. Alan Xu
  • Publisher : John Wiley & Sons
  • Release Date : 2011-04-12
  • Genre: Science
  • Pages : 520
  • ISBN 10 : 0470922796

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Analytical Methods for Therapeutic Drug Monitoring and Toxicology Excerpt :

This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. The summaries are structured monographs on 511 different drug entities detailing 964 different analytical methods, providing the reader with a thorough description of method validation. These analytical methods include not only high performance liquid chromatography (HPLC), but also gas chromatography (GC), immunoassay, electrophoresis, ultra performance liquid chromatography (UPLC) coupled with UV (UPLC-UV) detection and mass spectrometry (UPLC-MS/MS). With more detailed and complete summaries than sketchy and abbreviated formats used in the other books, this book provides a thorough description of method validation and results, as well as the operating parameters.

Therapeutic Drug Monitoring Book

Therapeutic Drug Monitoring


  • Author : Gerald E. Schumacher
  • Publisher : McGraw-Hill/Appleton & Lange
  • Release Date : 1995
  • Genre: Medical
  • Pages : 712
  • ISBN 10 : UOM:39015033266571

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Therapeutic Drug Monitoring Excerpt :

Handbook of Drug Monitoring Methods Book

Handbook of Drug Monitoring Methods


  • Author : Amitava Dasgupta
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-10-23
  • Genre: Medical
  • Pages : 441
  • ISBN 10 : 9781588297808

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Handbook of Drug Monitoring Methods Excerpt :

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology  1996  Book

Handbook of Analytical Therapeutic Drug Monitoring and Toxicology 1996


  • Author : Steven H.Y. Wong
  • Publisher : CRC Press
  • Release Date : 2017-11-22
  • Genre: Medical
  • Pages : 677
  • ISBN 10 : 9781351364270

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Handbook of Analytical Therapeutic Drug Monitoring and Toxicology 1996 Excerpt :

Adapting modern advances in analytical techniques to daily laboratory practices challenges many toxicologists, clinical laboratories, and pharmaceutical scientists. The Handbook of Analytical Therapeutic Drug Monitoring and Toxicology helps you keep abreast of the innovative changes that can make your laboratory - and the studies undertaken in it - a success. This volume simplifies your search for appropriate techniques, describes recent contributions from leading investigators, and provides valuable evaluations and advice.

Surviving Prescribing Book

Surviving Prescribing


  • Author : Anonim
  • Publisher : Remedica
  • Release Date : 2006-11
  • Genre: Drugs
  • Pages : 244
  • ISBN 10 : 9781901346930

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Surviving Prescribing Excerpt :

Prescribing medicine on the ward or in the clinic can be a daunting task. New doctors will recognise how easy it is to cause a patient harm, and also how hard it is to find helpful information. Hospital formularies are often excellent resources for drug doses, but what about the practical stuff? A patient is suffering from alcohol withdrawal...what regimens are available? How is 'patient-controlled analgesia' managed? This pocket-sized book, written by clinical pharmacists and doctors with years of experience, is a collection of handy hints, tips and protocols that will help doctors to prescribe simply, safely and with confidence.

Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology Book

Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology


  • Author : Irving Sunshine
  • Publisher : CRC Press
  • Release Date : 2019-10-07
  • Genre: Drug monitoring
  • Pages : 806
  • ISBN 10 : 0367402831

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Recent Developments in Therapeutic Drug Monitoring and Clinical Toxicology Excerpt :

Papers from the Second International Conference on TDM Toxicology (date and place not stated) describe research on various aspects of therapeutic monitoring pharmacology, selected high-performance liquid chromatographic methods, antiepileptics, substances subject to abuse, inorganics. Over 100 contr

Mass Spectrometry for the Clinical Laboratory Book

Mass Spectrometry for the Clinical Laboratory


  • Author : Hari Nair
  • Publisher : Academic Press
  • Release Date : 2016-11-02
  • Genre: Medical
  • Pages : 304
  • ISBN 10 : 9780128009925

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Mass Spectrometry for the Clinical Laboratory Excerpt :

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab. Provides readers with the keys to choosing, installing, and validating a mass spectrometry platform Offers tools to evaluate, validate, and troubleshoot the most common assays seen in clinical pathology labs Explains validation, ion suppression, interference testing, and quality control design to the detail that is required for implementation in the lab

Applied Pharmacokinetics   Pharmacodynamics Book
Score: 5
From 1 Ratings

Applied Pharmacokinetics Pharmacodynamics


  • Author : Michael E. Burton
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2006
  • Genre: Medical
  • Pages : 924
  • ISBN 10 : 0781744318

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Applied Pharmacokinetics Pharmacodynamics Excerpt :

The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.

Applied Pharmacokinetics Book
Score: 5
From 2 Ratings

Applied Pharmacokinetics


  • Author : William E. Evans
  • Publisher : Applied Therapeutics, Incorporated
  • Release Date : 1992
  • Genre: Medical
  • Pages : 1236
  • ISBN 10 : UOM:39015013811040

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Applied Pharmacokinetics Excerpt :

The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill Book

Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill


  • Author : Andrew A. Udy
  • Publisher : Springer
  • Release Date : 2017-09-18
  • Genre: Medical
  • Pages : 275
  • ISBN 10 : 9789811053368

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Antibiotic Pharmacokinetic Pharmacodynamic Considerations in the Critically Ill Excerpt :

This book provides unique insights into the issues that drive modified dosing regimens for antibiotics in the critically ill. Leading international authors provide their commentary alongside a summary of existing evidence on how to effectively dose antibiotics. Severe infection frequently necessitates admission to the intensive care unit (ICU). Equally, nosocomial sepsis often complicates the clinical course in ICU. Early, appropriate application of antibiotic therapy remains a cornerstone of effective management. However, this is challenging in the critical care environment, given the significant changes in patient physiology and organ function frequently encountered. Being cognisant of these factors, prescribers need to consider modified dosing regimens, not only to ensure adequate drug exposure, and therefore the greatest chance of clinical cure, but also to avoid encouraging drug resistance.