Third Generation EGFR Inhibitors Book

Third Generation EGFR Inhibitors


  • Author : Harun M. Patel
  • Publisher : Elsevier
  • Release Date : 2019-03-15
  • Genre: Medical
  • Pages : 290
  • ISBN 10 : 0081026617

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Third Generation EGFR Inhibitors Excerpt :

EGFR inhibitors are useful tools in cancer therapeutics, but resistance to the first generations have significantly increased, meaning a new generation of improved inhibitors are needed with better efficacy and lower toxicity. Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. Mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are then explored before a discussion of potential future trends. Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems is a guide for medicinal chemists, drug developer, and researchers investigating cancer therapeutics, supporting them in the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors. Includes full synthetic schemes of all approved and in-trial third generation inhibitors Highlights the emergence of fourth generation EGFR inhibitors and looks at how they may be able to overcome the constraints of third generation compounds Provides a structural correlation of third and fourth generation EGFR inhibitors and reviews both their design strategies and typical anticancer activity

Third Generation EGFR Inhibitors Book

Third Generation EGFR Inhibitors


  • Author : Harun M. Patel
  • Publisher : Elsevier
  • Release Date : 2018-11-27
  • Genre: Medical
  • Pages : 208
  • ISBN 10 : 9780081026625

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Third Generation EGFR Inhibitors Excerpt :

Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. Includes full synthetic schemes of all approved and in-trial third generation inhibitors Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity

Tyrosine Kinases as Druggable Targets in Cancer Book

Tyrosine Kinases as Druggable Targets in Cancer


  • Author : Huan Ren
  • Publisher : BoD – Books on Demand
  • Release Date : 2019-09-25
  • Genre: Medical
  • Pages : 134
  • ISBN 10 : 9781789848083

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Tyrosine Kinases as Druggable Targets in Cancer Excerpt :

Protein tyrosine kinase (PTK) deregulation contributes to growth of cancer and many other diseases. The development of small-molecule tyrosine kinase inhibitors (TKIs) that target the deregulated PTKs, such as epidermal growth factor receptor (EGFR) in non-small-cell lung cancer (NSCLC) and Bcr-ABL in chronic myeloid leukemia (CML), has revolutionized disease management. In this book, we examine a few aspects of PTKs and cancer, considering efficacy, predictive markers to therapeutic response, limitations, and future directions in TKI treatment. In this rapidly evolving field, overcoming therapeutic resistance is most challenging, and multi-targeting directs the next-generation TKIs and combination therapy as ongoing strategies in cancer treatment.

A Beginner s Guide to Targeted Cancer Treatments Book

A Beginner s Guide to Targeted Cancer Treatments


  • Author : Elaine Vickers
  • Publisher : John Wiley & Sons
  • Release Date : 2018-05-08
  • Genre: Medical
  • Pages : 360
  • ISBN 10 : 9781119126836

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A Beginner s Guide to Targeted Cancer Treatments Excerpt :

The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

Frontiers in Anti Cancer Drug Discovery  Volume 11 Book

Frontiers in Anti Cancer Drug Discovery Volume 11


  • Author : Atta-ur-Rahman
  • Publisher : Bentham Science Publishers
  • Release Date : 2020-09-01
  • Genre: Medical
  • Pages : 163
  • ISBN 10 : 9789811422126

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Frontiers in Anti Cancer Drug Discovery Volume 11 Excerpt :

Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The book series should prove to be of interest to all pharmaceutical scientists involved in research in anti-cancer drug design and discovery. The book series is essential reading to all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field. The eleventh volume of the series focuses on reviews on targeted therapies and drug delivery systems. This volume covers the following topics: - PI3K/Akt/mTOR Pathway in Acute Lymphoblastic Leukemia Targeted Therapies - Polymeric Nanomedicines in Treatment of Breast Cancer: Review of Contemporary Research - Treatment of Lung Cancer in the New Era - Oral Administration of Cancer Chemotherapeutics Exploiting Self-Nanoemulsifying Drug Delivery System: Recent Progress and Application - Targeting Approaches for the Diagnosis and Treatment of Cancer.

Current Drug Synthesis Book

Current Drug Synthesis


  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release Date : 2022-11-08
  • Genre: Science
  • Pages : 404
  • ISBN 10 : 9781119847250

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Current Drug Synthesis Excerpt :

The latest entry in the widely read Drug Synthesis series In Current Drug Synthesis, accomplished medicinal chemist and researcher Dr. Jie Jack Li and 27 expert coauthors deliver an authoritative and comprehensive discussion of the medicinal chemistry of current drugs, as well as the cutting-edge science involved in their synthesis. The book demystifies the process of modern drug discovery for both industry practitioners and students, while capturing the state-of-the-art techniques used to discover some of the most impactful medicines on the market today. Covering six different disease areas – including infectious disease, cancer, cardiovascular and metabolic disease, the central nervous system, anti-inflammatory disease, and a miscellaneous section – the book explores 18 different drugs before concluding with chapters on computational drug discovery and peptide drugs. Each chapter includes coverage of background material on a relevant drug class or disease indication and key aspects of drug discovery, including structure-activity relationships, pharmacokinetics, drug metabolism, efficacy, and safety. Readers will also find: Thorough introductions to drugs for infectious diseases, including relebactam, vaborbactam, and baloxavir marboxil In-depth treatments of cancer-treating drugs, including darolutamide, venetoclax, and osimertinib Comprehensive explorations of central nervous system drugs, including zuranolone and risdiplam Extensive discussions of computational drug discovery and peptide drugs Perfect for medicinal, organic, synthetic, and process chemists, Current Drug Synthesis will also earn a place in the libraries of research scientists working in lead optimization and process development, as well as graduate students studying organic chemistry, heterocyclic chemistry, or medicinal chemistry.

Central Nervous System Metastases Book

Central Nervous System Metastases


  • Author : Manmeet Ahluwalia
  • Publisher : Springer Nature
  • Release Date : 2019-11-05
  • Genre: Medical
  • Pages : 421
  • ISBN 10 : 9783030234171

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Central Nervous System Metastases Excerpt :

This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Therapeutic Strategies to Overcome ALK Resistance in Cancer Book

Therapeutic Strategies to Overcome ALK Resistance in Cancer


  • Author : Luc Friboulet
  • Publisher : Academic Press
  • Release Date : 2021-01-18
  • Genre: Science
  • Pages : 216
  • ISBN 10 : 9780128217795

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Therapeutic Strategies to Overcome ALK Resistance in Cancer Excerpt :

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment. Explains the biology of ALK RTK, focusing on its tissue expression, structure and functionality Presents an overview of current treatments and the benefits of ALK TKI in lung and other cancer types, such as ALCL, neuroblastoma and inflammatory myofibroblastic tumor Encompasses information on systemic treatments other than TKI, including chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC

Chemoinformatics Approaches to Structure  and Ligand Based Drug Design Book

Chemoinformatics Approaches to Structure and Ligand Based Drug Design


  • Author : Adriano D. Andricopulo
  • Publisher : Frontiers Media SA
  • Release Date : 2019-02-05
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 9782889457441

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Chemoinformatics Approaches to Structure and Ligand Based Drug Design Excerpt :

Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the use of chemoinformatics in drug design. To that end, experts in all areas of drug discovery have made their knowledge available through a series of articles that report state-of-the-art approaches. Readers are provided with outstanding contributions focusing on a wide variety of topics which will be of great value to those interested in the many different and exciting facets of drug design.

Targeted Therapies for Lung Cancer Book

Targeted Therapies for Lung Cancer


  • Author : Ravi Salgia
  • Publisher : Springer
  • Release Date : 2019-06-26
  • Genre: Medical
  • Pages : 238
  • ISBN 10 : 9783030178321

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Targeted Therapies for Lung Cancer Excerpt :

This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Practical Medical Oncology Textbook Book

Practical Medical Oncology Textbook


  • Author : Antonio Russo
  • Publisher : Springer Nature
  • Release Date : 2021-10-06
  • Genre: Medical
  • Pages : 1112
  • ISBN 10 : 9783030560515

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Practical Medical Oncology Textbook Excerpt :

This textbook combines essential information on clinical cancer medicine with a guide to the latest advances in molecular oncology and tumor biology. Providing a systematic overview of all types of solid tumors, including epidemiology and cancer prevention, genetic aspects of hereditary cancers, differential diagnosis, typical signs and symptoms, diagnostic strategies and staging, and treatment modalities, it also discusses new and innovative cancer treatments, particularly targeted therapy and immunotherapy. Expert commentaries at the end of each chapter highlight key points, offer insights, suggest further reading and discuss clinical application using case descriptions. This textbook is an invaluable, practice-oriented tool for medical students just beginning their clinical oncology studies, as well as for medical oncology residents and young professionals.

Protein Kinase Inhibitors Book

Protein Kinase Inhibitors


  • Author : Md. Imtaiyaz Hassan
  • Publisher : Academic Press
  • Release Date : 2022-05-19
  • Genre: Science
  • Pages : 830
  • ISBN 10 : 9780323913492

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Protein Kinase Inhibitors Excerpt :

Protein Kinase Inhibitors: From Discovery to Therapeutics offers a foundational, pragmatic overview of protein kinases inhibitors and their potential role in disease modulation and treatment. Here, international experts in the field offer an integrated discussion of kinase inhibitor biology, biomarker discovery, and methods for drug design and development. After a brief overview of kinases and kinase inhibitors, subsequent chapters discuss individual kinases that are representative of the wider kinases and kinase families, including their roles in disease pathogenesis, underlying mechanisms, potential inhibitors and their modes of action for therapeutic modulation. Several potential drugs under different stages of clinical trials are discussed, including their relevance to cancer, diabetes, obesity, cardiovascular, neurological, and auto-immune and inflammatory disease, among other disorders. The book also addresses the challenges and opportunities for future kinase inhibitor development. Provides a thorough overview of kinase inhibitor biology and its role in disease progression and modulation Examines protein kinase inhibitor drugs in various stages of clinical trials and development Offers methods and protocols for protein kinase inhibitor research studies and drug design and development Includes chapter contributions from international leaders in the field

AACR 2016  Abstracts 2697 5293 Book

AACR 2016 Abstracts 2697 5293


  • Author : American Association for Cancer Research (AACR)
  • Publisher : CTI Meeting Technology
  • Release Date : 2016-03-28
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 978186723xxxx

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AACR 2016 Abstracts 2697 5293 Excerpt :

The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.