Total Synthesis of Bioactive Natural Products Book

Total Synthesis of Bioactive Natural Products


  • Author : Goutam Brahmachari
  • Publisher : Elsevier
  • Release Date : 2019-04-27
  • Genre: Science
  • Pages : 350
  • ISBN 10 : 9780081028230

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Total Synthesis of Bioactive Natural Products Excerpt :

Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules Outlines each step of the process in detail, with full experimental information supported by extensive schemes Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Bioactive Natural Products Book

Bioactive Natural Products


  • Author : Goutam Brahmachari
  • Publisher : World Scientific
  • Release Date : 2012
  • Genre: Science
  • Pages : 670
  • ISBN 10 : 9789814335379

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Bioactive Natural Products Excerpt :

Bioactive natural products are a rich source of novel therapeutics. Thus, the search for bioactive molecules from nature continues to play an important role in fashioning new medicinal agents. This volume, which comprises sixteen chapters written by active researchers and leading experts in natural products chemistry, brings together an overview of current discoveries in this remarkable field. It also provides information on the industrial application of natural products for medicinal purposes. This book will serve as a valuable resource for researchers to predict promising leads for developing pharmaceuticals to treat various ailments and disease manifestations.

Multicomponent Reactions Book

Multicomponent Reactions


  • Author : K.L. Ameta, Ph.D.
  • Publisher : CRC Press
  • Release Date : 2017-09-20
  • Genre: Medical
  • Pages : 394
  • ISBN 10 : 9781315352732

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Multicomponent Reactions Excerpt :

This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation of various bioactive heterocycles due to their significant therapeutic potential.

Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds Book

Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds


  • Author : Shinsuke Inuki
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-11-23
  • Genre: Science
  • Pages : 106
  • ISBN 10 : 4431540431

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Total Synthesis of Bioactive Natural Products by Palladium Catalyzed Domino Cyclization of Allenes and Related Compounds Excerpt :

The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Total Synthesis of Natural Products Book

Total Synthesis of Natural Products


  • Author : Jie Jack Li
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-14
  • Genre: Science
  • Pages : 279
  • ISBN 10 : 9783642340659

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Total Synthesis of Natural Products Excerpt :

'Total Synthesis of Natural Products' is written and edited by some of today's leaders in organic chemistry. Eleven chapters cover a range of natural products, from steroids to alkaloids. Each chapter contains an introduction to the natural product in question, descriptions of its biological and pharmacological properties and outlines of total synthesis procedures already carried out. Particular emphasis is placed on novel methodologies developed by the respective authors and their research groups. This text is ideal for graduate and advanced undergraduate students, as well as organic chemists in academia and industry.

Bioactive Natural Products Book

Bioactive Natural Products


  • Author : Goutam Brahmachari
  • Publisher : John Wiley & Sons
  • Release Date : 2015-03-23
  • Genre: Science
  • Pages : 544
  • ISBN 10 : 9783527337941

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Bioactive Natural Products Excerpt :

Natural compounds, which have evolved their function over millions of years, are often more efficient than man-made compounds if a specific biological activity is needed, e.g. as an enzyme inhibitor or as a toxin to kill a cancer cell. This book comprising of sixteen technical chapters, highlights the chemical and biological aspects of potential natural products with an intention of unravelling their pharmaceutical applicability in modern drug discovery processes. Key features: Covers the synthesis, semi-synthesis and also biosynthesis of potentially bioactive natural products Features chemical and biological advances in naturally occurring organic compounds describing their chemical transformations, mode of actions, and structure-activity relationships 40 expert scientists from around the world report their latest findings and outline future opportunities for the development of novel and highly potent drugs based on natural products operating at the interface of chemistry and biology Forward-looking: Addresses opportunities and cutting-edge developments rather than well-documented basic knowledge, pinpoints current trends and future directions in this rapidly-evolving field Application-oriented: Throughout the book, the focus is on actual and potential applications in pharmacology and biotechnology This book is an essential resource for natural products chemists, medicinal chemists, biotechnologists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries.

Studies in Natural Products Chemistry Book

Studies in Natural Products Chemistry


  • Author : Atta-ur- Rahman
  • Publisher : Elsevier
  • Release Date : 2012-12-06
  • Genre: Science
  • Pages : 438
  • ISBN 10 : 9780444595157

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Studies in Natural Products Chemistry Excerpt :

Natural products play an integral and ongoing role in promoting numerous aspects of scientific advancement, and many aspects of basic research programs are intimately related to natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 37 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable source for researchers and engineers working in natural products and medicinal chemistry. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field A valuable source for researchers and engineers working in natural product and medicinal chemistry

Studies in Natural Products Chemistry Book

Studies in Natural Products Chemistry


  • Author : Atta-ur-Rahman
  • Publisher : Elsevier
  • Release Date : 2003-07-08
  • Genre: Science
  • Pages : 812
  • ISBN 10 : 0080542050

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Studies in Natural Products Chemistry Excerpt :

Studies in Natural Products Chemistry: Bioactive Natural Products (Part I) contains articles written by leading authorities in their respective fields of research. It presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. Volume 28 is part of a great family of useful reference books Illustrates the types of critical discoveries that emerge from the interface of chemistry and biology Contributions are from well-respected authors

Medicinal Chemistry of Bioactive Natural Products Book

Medicinal Chemistry of Bioactive Natural Products


  • Author : Xiao-Tian Liang
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-17
  • Genre: Science
  • Pages : 336
  • ISBN 10 : 9780471739333

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Medicinal Chemistry of Bioactive Natural Products Excerpt :

Current discoveries and research into bioactive naturalproducts Medicinal Chemistry of Bioactive Natural Products provides amuch-needed survey of bioactive natural products and theirapplications in medicinal chemistry. This comprehensive referencefeatures articles by some of the world's leading scientists in thefield on discovery, structure elucidation, and elegant syntheticstrategies--developed for natural products--with an emphasis on thestructure activity relationship of bioactive natural products. Thetopics have been carefully chosen on the basis of relevance tocurrent research and to importance as clinicially usefulagents. Rather than attempting to be a comprehensive encyclopedia ofbioactive natural products, Medicinal Chemistry of BioactiveNatural Products guides the reader to the key developments in thefield. By providing not only practical detail but a historicalperspective on the chemistry and biology of the compounds underconsideration, the book serves as a handy resource for researchersin their own work developing pharmaceuticals, and as an inspiringintroduction for young scientists to the dynamic field of bioactivenatural products research. Enhanced by examples with updated research results, the discussioncovers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and itsanalogs * The antimalarial properties of the traditional Chinese medicine,Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer'sdisease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIVagents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and theirstructurally modified mimics

Studies in Natural Products Chemistry Book

Studies in Natural Products Chemistry


  • Author : Anonim
  • Publisher : Elsevier
  • Release Date : 2014-03-05
  • Genre: Science
  • Pages : 500
  • ISBN 10 : 9780444632821

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Studies in Natural Products Chemistry Excerpt :

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of natural products. Describes the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents exciting sources of new pharmacophores

Efficiency in Natural Product Total Synthesis Book

Efficiency in Natural Product Total Synthesis


  • Author : Pei-Qiang Huang
  • Publisher : John Wiley & Sons
  • Release Date : 2018-07-24
  • Genre: Science
  • Pages : 512
  • ISBN 10 : 9781118940211

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Efficiency in Natural Product Total Synthesis Excerpt :

Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals