Postmortem Toxicology Book

Postmortem Toxicology


  • Author : Timothy P. Rohrig
  • Publisher : Academic Press
  • Release Date : 2019-02-22
  • Genre: Law
  • Pages : 266
  • ISBN 10 : 9780128151648

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Postmortem Toxicology Excerpt :

Postmortem Toxicology addresses the various aspects of the practice of forensic postmortem toxicology from a viewpoint of elements which must be taken into consideration for proper interpretation of the toxicological result, not in a vacuum but in a more holistic and global sense. The volume examines pre-analytical factors, storage containers/conditions, prior medical interventions and therapy, along with information from the scene investigation and anatomical findings. This reference also provides explanation of the complicating conditions for the interpretation of the toxicological results due to postmortem decomposition, embalming artifacts and the postmortem redistribution of drugs. Tolerance is also discussed as an aid to interpreting results from a habitual/chronic user of medications and/or drugs of abuse. The book is geared towards the current practitioner; however, it is written to be used as a valuable reference for a graduate or post-graduate level courses in forensic toxicology or forensic pathology. Presents a holistic approach to the interpretation of toxicology results Covers pre-analytical factors, storage containers/conditions, prior medical interventions, therapy, and much more Written for the current practitioner, but an excellent resource for graduate level students training in the field of forensic toxicology

Public Health Consequences of E Cigarettes Book

Public Health Consequences of E Cigarettes


  • Author : National Academies of Sciences, Engineering, and Medicine
  • Publisher : National Academies Press
  • Release Date : 2018-05-18
  • Genre: Medical
  • Pages : 774
  • ISBN 10 : 9780309468374

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Public Health Consequences of E Cigarettes Excerpt :

Millions of Americans use e-cigarettes. Despite their popularity, little is known about their health effects. Some suggest that e-cigarettes likely confer lower risk compared to combustible tobacco cigarettes, because they do not expose users to toxicants produced through combustion. Proponents of e-cigarette use also tout the potential benefits of e-cigarettes as devices that could help combustible tobacco cigarette smokers to quit and thereby reduce tobacco-related health risks. Others are concerned about the exposure to potentially toxic substances contained in e-cigarette emissions, especially in individuals who have never used tobacco products such as youth and young adults. Given their relatively recent introduction, there has been little time for a scientific body of evidence to develop on the health effects of e-cigarettes. Public Health Consequences of E-Cigarettes reviews and critically assesses the state of the emerging evidence about e-cigarettes and health. This report makes recommendations for the improvement of this research and highlights gaps that are a priority for future research.

Toxicology Book
Score: 5
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Toxicology


  • Author : Hans Marquardt
  • Publisher : Academic Press
  • Release Date : 1999-10-05
  • Genre: Medical
  • Pages : 1330
  • ISBN 10 : 9780080543116

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Toxicology Excerpt :

Toxicology is a comprehensive text for researchers and graduate students in toxicology and public health. It addresses every aspect of the field, starting with the fundamentals and incorporating such areas as organ toxicology, applications, and environmental toxicology. In addition to covering the traditional subject matter of toxicology, special emphasis has been placed on recent areas of interest, such as risk assessment, apoptosis, and methodical developments. Key Features * Comprehensive text, covering all aspects of the field of toxicology * Analyzes the importance of toxicokinetics and metabolism as well as cellular targets for the mechanisms of toxic effects * Identifies the various classes of chemical compounds responsible for the toxic effects * Describes the approaches and methods used by various disciplines which investigate toxic effects and their prevention * Adapted from a very successful German text, this edition is completely revised and expanded * The text is well illustrated with diagrams, charts, and tables

Acute Toxicology Testing Book

Acute Toxicology Testing


  • Author : Shayne C. Gad
  • Publisher : Academic Press
  • Release Date : 1997-10-27
  • Genre: Medical
  • Pages : 534
  • ISBN 10 : 008052592X

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Acute Toxicology Testing Excerpt :

Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health. Key Features * Over 100 tables summarizing and interpreting results * Complete coverage of all major test designs and their limitations and advantages * Current status of alternative test designs and models

Veterinary Toxicology Book

Veterinary Toxicology


  • Author : Ramesh C. Gupta
  • Publisher : Elsevier
  • Release Date : 2011-04-28
  • Genre: Medical
  • Pages : 1224
  • ISBN 10 : 0080481604

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Veterinary Toxicology Excerpt :

Veterinary Toxicology, 2nd edition is a unique single reference that teaches the basic principles of veterinary toxicology and builds upon these principles to offer an essential clinical resource for those practicing in the field. This reference book is thoroughly updated with new chapters and the latest coverage of topics that are essential to research veterinary toxicologists, students, professors, clinicians and environmentalists. Key areas include melamine and cyanuric acid, toxicogenomics, veterinary medical geology, toxic gases, toxicity and safety evaluation of new veterinary pharmaceuticals and much more. The 2nd edition of this popular book represents the collective wisdom of leading contributors worldwide and continues to fill an undeniable need in the literature relating to veterinary toxicology. New chapters covering important and timely topics such as melamine and cyanuric acid, toxicogenomics, toxic gases and veterinary medical geology Expanded look at international topics, such as epidemiology of animal poisonings, regulatory guidelines and poisonous plants in Europe Heavily contributed book with chapters written by qualified and well-experienced authorities across all areas of veterinary toxicology Problem solving strategies are offered for treatment as well as in-depth knowledge of the basic mechanisms of veterinary toxicology

An Introduction to Toxicology Book

An Introduction to Toxicology


  • Author : Philip C. Burcham
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-19
  • Genre: Medical
  • Pages : 327
  • ISBN 10 : 9781447155539

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An Introduction to Toxicology Excerpt :

This book provides a readable introduction to modern toxicology with a particular focus on the mechanisms underlying the induction of toxicity by foreign substances. Since bioactivation is central to many toxic syndromes, special interest is devoted to chemicals that undergo conversion to toxic metabolites that induce toxic effects as diverse as cancer, birth defects and organ injury. The molecular consequences accompanying damage to cellular DNA and proteins is explored together with the relevance of toxicological paradigms to human diseases caused by alcohol and tobacco. The discipline of toxicology has developed rapidly since the thalidomide disaster in the 1960’s as scientists worldwide seek to understand the adverse health effects of human medicines, environmental pollutants, consumer chemicals and industrial reagents. An Introduction to Toxicology is intended to supplement the recommended reading list of undergraduate and graduate programs in toxicology and pharmacology as an enjoyable, accessible primer with illustrations that “unpack” the concepts being discussed in the text. ​

The History of Alternative Test Methods in Toxicology Book

The History of Alternative Test Methods in Toxicology


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-10-20
  • Genre: Medical
  • Pages : 352
  • ISBN 10 : 9780128136980

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The History of Alternative Test Methods in Toxicology Excerpt :

The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology u

An Introduction to Aquatic Toxicology Book

An Introduction to Aquatic Toxicology


  • Author : Mikko Nikinmaa
  • Publisher : Elsevier
  • Release Date : 2014-07-01
  • Genre: Science
  • Pages : 252
  • ISBN 10 : 9780124115811

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An Introduction to Aquatic Toxicology Excerpt :

An Introduction to Aquatic Toxicology is an introductory reference for all aspects of toxicology pertaining to aquatic environments. As water sources diminish, the need to understand the effects that contaminants may have on aquatic organisms and ecosystems increases in importance. This book will provide you with a solid understanding of aquatic toxicology, its past, its cutting-edge present and its likely future. An Introduction to Aquatic Toxicology will introduce you to the global issue of aquatic contamination, detailing the major sources of contamination, from where they originate, and their effects on aquatic organisms and their environment. State-of-the-art toxicological topics covered include nanotoxicology, toxicogenomics, bioinformatics, transcriptomics, metabolomics, as well as water management and the toxicological effects of major environmental issues such as algal blooms, climate change and ocean acidification. This book is intended for anyone who wants to know more about the impact of toxicants on aquatic organisms and ecosystems, or to keep up to date with recent and future developments in the field. Provides with the latest perspectives on the impacts of toxicants on aquatic environments, such as nanotoxicology, toxicogenomics, ocean acidification and eutrophication Offers a complete overview, beginning with the origins of aquatic toxicology and concluding with potential future challenges Includes guidance on testing methods and a glossary of aquatic toxicology terms.

Assessing Ocular Toxicology in Laboratory Animals Book

Assessing Ocular Toxicology in Laboratory Animals


  • Author : Andrea B Weir
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-04
  • Genre: Medical
  • Pages : 322
  • ISBN 10 : 9781627031646

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Assessing Ocular Toxicology in Laboratory Animals Excerpt :

Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.

Veterinary Toxicology for Australia and New Zealand Book

Veterinary Toxicology for Australia and New Zealand


  • Author : Rosalind Dalefield
  • Publisher : Elsevier
  • Release Date : 2017-06-23
  • Genre: Medical
  • Pages : 628
  • ISBN 10 : 9780127999128

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Veterinary Toxicology for Australia and New Zealand Excerpt :

Veterinary Toxicology for Australia and New Zealand is a reference suited to the unique challenges of veterinary practice in Australia and New Zealand. Both streamlined and thorough in its coverage of poisons and treatments for those locations, this focused approach allows readers to quickly find relevant information that is presented in a concise and logical manner that is useful to clinicians. The authors draw upon a wealth of knowledge of the particularities of toxicology in Australia and New Zealand to present readers with the up-to-date information required to efficiently and effectively diagnose and treat their patients. Highlights toxins of specific concern in Australia and New Zealand Structures information in a logical way so that it can be located quickly Offers up-to-date information on current and emerging risks

Toxicological Risk Assessment and Multi System Health Impacts from Exposure Book

Toxicological Risk Assessment and Multi System Health Impacts from Exposure


  • Author : Aristidis M. Tsatsakis
  • Publisher : Elsevier
  • Release Date : 2021-08-01
  • Genre: Medical
  • Pages : 684
  • ISBN 10 : 9780323853583

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Toxicological Risk Assessment and Multi System Health Impacts from Exposure Excerpt :

Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. • Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field • Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease • Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research

Molecular Toxicology Book

Molecular Toxicology


  • Author : Nick Plant
  • Publisher : Taylor & Francis
  • Release Date : 2021-02-26
  • Genre: Science
  • Pages : 164
  • ISBN 10 : 9781000150216

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Molecular Toxicology Excerpt :

Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e.g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

Concepts and Applications in Veterinary Toxicology Book

Concepts and Applications in Veterinary Toxicology


  • Author : PK Gupta
  • Publisher : Springer
  • Release Date : 2019-08-12
  • Genre: Medical
  • Pages : 350
  • ISBN 10 : 9783030222505

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Concepts and Applications in Veterinary Toxicology Excerpt :

This book: “Concepts and Applications in Veterinary Toxicology: An Interactive Guide”: covers a broad spectrum of topics related to students specializing in veterinary toxicology and for veterinary medical practitioners. Since the major emphasis of the book is to teach veterinary students, therefore more attention has been given to common toxicants to which several species are exposed including pet animals. The subject of veterinary toxicology is complicated greatly by the wide variations in responses of domestic, companion, aquatic, wild, and zoo species to toxicants. Therefore, emphasis has also been given to species variation and diagnostic toxicology including clinical management that is more relevant to veterinary profession. Key Features · Highlights specialized topics essential for veterinary specialists. · Covers a variety of common toxicants to which several species including pet animals are exposed. · Includes sample questions and answers that are extremely valuable for students, clinical pharmacists, teachers, and academicians in preparing for their board and other examinations.

In Vitro Toxicology Book

In Vitro Toxicology


  • Author : Alok Dhawan
  • Publisher : Academic Press
  • Release Date : 2017-11-13
  • Genre: Science
  • Pages : 248
  • ISBN 10 : 9780128047712

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In Vitro Toxicology Excerpt :

In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. Discusses new techniques and protocols in a clear and concise manner includes examinations of nanotoxicity, genotoxicity and carcinogenicity Explains practical laboratory methods and the theories behind in vitro testing

Basic Science in Toxicology Book

Basic Science in Toxicology


  • Author : Glyn N. Volans
  • Publisher : Taylor & Francis Group
  • Release Date : 1990
  • Genre: Medical
  • Pages : 712
  • ISBN 10 : UCAL:$B327893

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Basic Science in Toxicology Excerpt :