Translational Inflammation Book

Translational Inflammation


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-11-24
  • Genre: Medical
  • Pages : 294
  • ISBN 10 : 9780128138335

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Translational Inflammation Excerpt :

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Translational Systems Biology Book

Translational Systems Biology


  • Author : Yoram Vodovotz
  • Publisher : Elsevier
  • Release Date : 2014-10-08
  • Genre: Science
  • Pages : 178
  • ISBN 10 : 9780123978905

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Translational Systems Biology Excerpt :

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams

Translational Pain Research Book

Translational Pain Research


  • Author : Lawrence Kruger
  • Publisher : CRC Press
  • Release Date : 2009-11-24
  • Genre: Health & Fitness
  • Pages : 432
  • ISBN 10 : 9781439812105

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Translational Pain Research Excerpt :

One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Translational Inflammation Book

Translational Inflammation


  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-12-15
  • Genre: Medical
  • Pages : 200
  • ISBN 10 : 0128138327

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Translational Inflammation Excerpt :

Translational Inflammation links laboratory and clinical data within primary and secondary care to clinical research data and offers a holistic and innovative approach to chronic inflammation and ageing. Understanding the role of inflammation as a part of clinical disease states is becoming a valuable tool in both direct treatment and the development of therapeutics. Translational Inflammation, the 4th volume in the Perspectives in Translational Cell Biology series, offers content for professors, students and researchers across basic and translational biology. Emphasizes the role of inflammation in disease and therapeutic approaches Integrates broad concepts relating inflammation to other fields Offers a bridge to review literature and primary research on the inflammatory response towards medical application

Translational Studies on Inflammation Book

Translational Studies on Inflammation


  • Author : Ane C.F. Nunes
  • Publisher : BoD – Books on Demand
  • Release Date : 2020-01-08
  • Genre: Medical
  • Pages : 249
  • ISBN 10 : 9781789843576

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Translational Studies on Inflammation Excerpt :

Inflammation is known worldwide, from the bench to the bedside, but it is a hard theme to approach with one single point of view.In this sense, a selection of translational studies would support the medical-scientific community to better understand the complex network of the inflammatory process, its maintenance, and potential treatment targets. The eleven chapters that compose this book present interesting insights into inflammation and its mechanisms, merging classic background with innovative approaches. From the molecular basis to experimental models, the chapters selected for this book bring to readers at different academic levels updated and practical data on inflammation. Find out what drives interdisciplinary medical research on inflammation and enjoy this informative collection.

Handbook of translational medicine Book

Handbook of translational medicine


  • Author : Josep M. Llovet
  • Publisher : Edicions Universitat Barcelona
  • Release Date : 2016-10-05
  • Genre: Medical
  • Pages : 245
  • ISBN 10 : 9788447540303

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Handbook of translational medicine Excerpt :

This handbook aims to capture the basic concepts of translational medicine, understood as a branch of the biomedical field that translates discoveries into the clinical setting. This discipline is currently closing the gap between basic science and clinical research. The book is intended to be straightforward, easy-to-read, intelligible and practical. It describes the basic principles of translational medicine, including major advances in genomics, new technologies, the processing of big data and biobanks. Regarding the biological foundations of translational medicine, we address concepts related to the molecular basis of cancer, inflammation, angiogenesis, stem cells and experimental models. More specifically on translational medicine, we present discoveries and breakthroughs in oncology, neuroscience, metabolic and systemic diseases, and public health. Finally, we have specific sections focused on clinical trials and biomarkers in the genomic era, advances in imaging techniques and entrepreneurship and innovation. Our purpose is to offer a manageable text to guide graduate and post-graduate students, professionals and researchers in biomedicine through the major technologies and advances that have occurred in the translational field. It is also intended to aid residents, fellows and physician-scientists working in hospitals and academic institutions.

Translational Immunology Book

Translational Immunology


  • Author : Seng-Lai Tan
  • Publisher : Academic Press
  • Release Date : 2015-11-18
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9780128017579

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Translational Immunology Excerpt :

Translational Immunology: Mechanisms and Pharmacologic Approaches highlights and summarizes the most important advances in human immunology, clinical translations, new tools to analyze therapeutic targets, and new pharmacological approaches for autoimmunity, inflammatory disorders, and cancer. The book is an essential resource for those seeking to understand the potential translational applications of burgeoning studies in human immunology, helping readers make sense of the existing and emerging scientific advances. The book grounds fundamental science in the translational realm, providing insights from world renowned researchers at the top of their game in their respective fields, in both industry and academic settings. Readers will gain an understanding of the rationale and mechanisms underlying current and emerging pharmacologic approaches for interventional immunology, the gaps therein, and new ideas for better and safer therapeutic approaches, and physicians will glean information about pharmacological limitations in altering disease progression and complications. This reference on the translational realization of the burgeoning findings in immunology provides a go-to reference for experienced professional clinicians, researchers, industry scientists, and those seeking more information on the field. Delivers comprehensive coverage of seminal human immunology discoveries and the resulting impact on therapeutic strategies Presents potential novel targets and approaches for clinical applications in organ specific and systemic autoimmunity, transplant rejection, cancer, and vaccine development Discusses lessons learned from successful and failed clinical trials with specific interventions, including pharmacological issues and limitations, and complications due to immunosuppression Provides information on new strategies and outstanding issues that should be addressed in future research

Lung Inflammation in Health and Disease  Volume I Book

Lung Inflammation in Health and Disease Volume I


  • Author : Yong-Xiao Wang
  • Publisher : Springer Nature
  • Release Date : 2021-03-31
  • Genre: Medical
  • Pages : 409
  • ISBN 10 : 9783030630461

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Lung Inflammation in Health and Disease Volume I Excerpt :

Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung disease are neither effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers,

Translational Pain Research  Comparing preclinical studies and clinical pain management  Lost in translation  Book

Translational Pain Research Comparing preclinical studies and clinical pain management Lost in translation


  • Author : Jianren Mao
  • Publisher : Nova Publishers
  • Release Date : 2006
  • Genre: Medical
  • Pages : 370
  • ISBN 10 : 1600212050

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Translational Pain Research Comparing preclinical studies and clinical pain management Lost in translation Excerpt :

Basic science and clinical pain research is particularly challenging for several reasons. First, pain is a subjective experience in response to nociception that follows actual or potential tissue damage. Since the ability to respond to this warning signal is essential for our survival, the nociceptive system that produces and transmits nociceptive signals is remarkably redundant and involves diffuse regions of the central nervous system. Second, unlike other sensory modalities, pain is a multi-dimensional experience including at least cognitive, affective, and sensory-discriminative components. Third, pain experiences can be influenced by psychological, socioeconomic, cultural, and genetic predispositions, making it exceedingly complicated to study pain and pain modulation. The topics covered in this volume are carefully selected and directly related to the daily practice of pain medicine. These topics include 1) central mechanisms of pain and pain modulation (Dickenson, Donovan-Rodriguez, Mattews) and clinical use of ion channel blockers (Chen); 2) spinal glutamatergic mechanisms (Guo, Dubner, Ren) and issues related to glutamate receptor antagonists in pain management (Mao); 3) basic science of opioid analgesics (Gintzler, Chakrabarti) and clinical opioid use (Smith, McCleane); 4) inflammatory cytokines (Samad) and clinical use of anti-inflammatory drugs (Fink, Brenner); 5) role of the sympathetic nervous system in pain mechanisms and its relation to clinical pain management (Sharma, Raja); 6) preclinical studies on tricyclic antidepressants (Gerner, Wang) and clinical use of antidepressants in pain management (Greenberg); 7) developing pain pathways and analgesic mechanisms during the developmental stage (Fitzgerald) and challenges of pediatric pain management (Lebel); 8) basic science mechanisms of serotonin agonists and their use in the clinical management of migraine headache (Biondi); 9) clinical research on gender differences in clinical pain and their impli

Nanomedicine for Inflammatory Diseases Book

Nanomedicine for Inflammatory Diseases


  • Author : Lara Scheherazade Milane
  • Publisher : CRC Press
  • Release Date : 2017-09-19
  • Genre: Medical
  • Pages : 353
  • ISBN 10 : 9781498749800

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Nanomedicine for Inflammatory Diseases Excerpt :

Nanomedicine for Inflammatory Diseases is a cutting-edge resource for clinicians and scientists alike, working at the intersection of development and clinical therapeutics. This text is ideal for graduate level courses in nanomedicine, translational medicine, or inflammatory disease. This book is a progressive hallmark in translational medicine as it unites clinicians treating inflammatory disease with scientists developing experimental nanomedicine therapeutics. The commonality is made through a translational nanomedicine expert – bridging the gap between the laboratory benchtop and the clinical bedside.

Advances in Immunology Book

Advances in Immunology


  • Author : Frederick W. Alt
  • Publisher : Elsevier
  • Release Date : 2011-07-29
  • Genre: Medical
  • Pages : 400
  • ISBN 10 : 0080475787

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Advances in Immunology Excerpt :

Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Anaesthesia  Pharmacology  Intensive Care and Emergency A P I C E  Book

Anaesthesia Pharmacology Intensive Care and Emergency A P I C E


  • Author : Antonino Gullo
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-22
  • Genre: Medical
  • Pages : 260
  • ISBN 10 : 9788847055162

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Anaesthesia Pharmacology Intensive Care and Emergency A P I C E Excerpt :

Innovation, training and research are the pillars that support a process deriving from basic science and multi-professional/multidisciplinary interventions. The APICE 2012 yearbook deals with several innovations for optimising prevention and management measures for the critically ill, by integrating diagnostic procedures with pharmacological and technological options. Peri- and postoperative managements as well as treatment of surgical infections and of pain, new and old artificial ventilation strategies are some of the most relevant topics the volume deal with in this new edition. The volume focuses also on the improvement standards and quality of care; on the expanding concept of clinical governance and professionalism and on the importance of ethical principles for establishing a process of patient-centered and evidence-based care.

Smoking and Lung Inflammation Book

Smoking and Lung Inflammation


  • Author : Thomas J. Rogers
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-12
  • Genre: Medical
  • Pages : 213
  • ISBN 10 : 9781461473510

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Smoking and Lung Inflammation Excerpt :

Smoking and Lung Inflammation is the first book directly related to chronic lung inflammation of its kind in several respects. First, the it focuses on both basic and clinical research on COPD, and the inflammatory mechanisms that function in these diseases. Second, it is unique with respect to scope of the discussion of the unusual characteristics of the immune response which occurs in these patients. Third, it includes knowledge being gained from translational research conducted through clinical trials at several Medical Schools in the United States. Not only is this research providing information about novel drugs and therapies, but it is also advancing our understanding of the genetics of these diseases. This work will illuminate the molecular basis for these diseases, and hopefully will permit us to individualize the therapies for these diseases.

Lung Inflammation in Health and Disease  Volume II Book

Lung Inflammation in Health and Disease Volume II


  • Author : Yong-Xiao Wang
  • Publisher : Springer Nature
  • Release Date : 2021-05-21
  • Genre: Medical
  • Pages : 384
  • ISBN 10 : 9783030687489

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Lung Inflammation in Health and Disease Volume II Excerpt :

Lung diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma. Each year, tens of millions of people develop and can die from lung infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for some patients. Current treatment options for lung disease are neither always effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with n