Translational Research in Stroke Book

Translational Research in Stroke


  • Author : Paul A. Lapchak
  • Publisher : Springer
  • Release Date : 2017-12-20
  • Genre: Medical
  • Pages : 581
  • ISBN 10 : 9789811058042

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Translational Research in Stroke Excerpt :

This book mainly discusses the current status of stroke transnational research and allows the reader to understand the interplay of common comorbidities in the stroke population such as diabetes and hypertension, and provides insight into stroke targets to promote cell survival, angiogenesis, neurogenesis, and most importantly, functional recovery after stroke. Throughout the world, stroke is still a leading cause of mortality and morbidity; each year approximately 15 million people worldwide suffer from stroke. Stroke is now the leading cause of death and disability in China. Large communities of stroke survivors are eagerly awaiting scientific advances in transnational stroke research that would offer neuroprotective therapeutics for acute stroke management, or rehabilitation and regenerative strategies utilizing novel stem cell-based approaches. While research is ongoing, the Editors have compiled this volume to help the further understanding of the pathophysiology of stroke and to review and identify future potential biomarkers. The book is written for students, researchers and physicians in neurosciences, neurology and neuroradiology.

Translational Stroke Research Book

Translational Stroke Research


  • Author : Paul A. Lapchak
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-03-23
  • Genre: Medical
  • Pages : 923
  • ISBN 10 : 9781441995292

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Translational Stroke Research Excerpt :

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

Rational Basis for Clinical Translation in Stroke Therapy Book

Rational Basis for Clinical Translation in Stroke Therapy


  • Author : Giuseppe Micieli
  • Publisher : CRC Press
  • Release Date : 2014-08-27
  • Genre: Medical
  • Pages : 538
  • ISBN 10 : 9781466594975

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Rational Basis for Clinical Translation in Stroke Therapy Excerpt :

Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs that showed neuroprotection in the experimental setting failed to translate into the clinic because of their toxicity or lack of efficacy. Researchers in the field now face the crucial need to develop effective stroke therapies and successfully translate novel strategies into the clinical setting. Rational Basis for Clinical Translation in Stroke Therapy presents the most recent promising preclinical approaches and the most updated clinical evidence for treating stroke patients. By bringing together the experience of accomplished stroke researchers and clinicians, the book is a useful tool for improving the treatment and management of stroke patients. The book describes current approaches for the management of stroke patients including thrombolysis and mechanical recanalization procedures as well as other clinically relevant topics such as diagnosis, imaging, risk factors, and prevention. Also described are emerging interventions based on the use of stem cells, botulinum toxin, and antidepressants which complement emergency stroke treatment and conventional rehabilitation procedures. Clinical approaches are integrated with the most promising therapeutic opportunities based on targeting the immune system, hypothermia, and postconditioning. The book also covers issues related to the improvement of R&D strategies in stroke therapeutics, aimed at the implementation of preclinical approaches with stroke model guidelines and at the optimization of clinical trial design. This volume is a reference for all those interested in the rational development of novel stroke therapeutics.

Translational Stroke Research Book

Translational Stroke Research


  • Author : Springer
  • Publisher : Unknown
  • Release Date : 2012-03-27
  • Genre: Uncategoriezed
  • Pages : 948
  • ISBN 10 : 1441995315

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Translational Stroke Research Excerpt :

Acute Brain Impairment Book

Acute Brain Impairment


  • Author : Bridget Martinez
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-11-23
  • Genre: Science
  • Pages : 348
  • ISBN 10 : 9781782629504

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Acute Brain Impairment Excerpt :

Translational Stroke Research Book

Translational Stroke Research


  • Author : Paul A. Lapchak
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-03-23
  • Genre: Medical
  • Pages : 923
  • ISBN 10 : 9781441995292

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Translational Stroke Research Excerpt :

This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

Cell Therapy Against Cerebral Stroke Book

Cell Therapy Against Cerebral Stroke


  • Author : Kiyohiro Houkin
  • Publisher : Springer
  • Release Date : 2017-01-06
  • Genre: Medical
  • Pages : 156
  • ISBN 10 : 9784431560593

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Cell Therapy Against Cerebral Stroke Excerpt :

This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.

Translational Research in Coronary Artery Disease Book

Translational Research in Coronary Artery Disease


  • Author : Wilbert S. Aronow
  • Publisher : Academic Press
  • Release Date : 2015-10-29
  • Genre: Medical
  • Pages : 244
  • ISBN 10 : 9780128026052

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Translational Research in Coronary Artery Disease Excerpt :

Translational Research in Coronary Artery Disease: Pathophysiology to Treatment covers the entire spectrum of basic science, genetics, drug treatment, and interventions for coronary artery disease. With an emphasis on vascular biology, this reference fully explains the fundamental aspects of coronary artery disease pathophysiology. Included are important topics, including endothelial function, endothelial injury, and endothelial repair in various disease states, vascular smooth muscle function and its interaction with the endothelium, and the interrelationship between inflammatory biology and vascular function. By providing this synthesis of current research literature, this reference allows the cardiovascular scientist and practitioner to access everything they need from one source. Provides a concise summary of recent developments in coronary and vascular research, including previously unpublished data Summarizes in-depth discussions of the pathobiology and novel treatment strategies for coronary artery disease Provides access to an accompanying website that contains photos and videos of noninvasive diagnostic modalities for evaluation of coronary artery disease

Principles of Translational Science in Medicine Book

Principles of Translational Science in Medicine


  • Author : Martin Wehling
  • Publisher : Academic Press
  • Release Date : 2015-04-02
  • Genre: Science
  • Pages : 364
  • ISBN 10 : 9780128007211

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Principles of Translational Science in Medicine Excerpt :

Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine. Provides an in-depth description of novel tools for the assessment of translatability of trials to balance risk and improve projects at any given stage of product development New chapters deal with translational issues in the fastest growing population (the elderly), case studies, translatability assessment tools, and advances in nanotherapies Details IPR issues of translation, especially for public-private-partnerships Contains contributions from world leaders in translational medicine, including the former NIH director and authorities from various European regulatory institutions

Neuroprotective Therapy for Stroke and Ischemic Disease Book

Neuroprotective Therapy for Stroke and Ischemic Disease


  • Author : Paul A. Lapchak
  • Publisher : Springer
  • Release Date : 2018-07-17
  • Genre: Medical
  • Pages : 795
  • ISBN 10 : 3319832727

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Neuroprotective Therapy for Stroke and Ischemic Disease Excerpt :

A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

Translational Research in Traumatic Brain Injury Book

Translational Research in Traumatic Brain Injury


  • Author : Daniel Laskowitz
  • Publisher : CRC Press
  • Release Date : 2015-12-01
  • Genre: Medical
  • Pages : 412
  • ISBN 10 : 9781498766579

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Translational Research in Traumatic Brain Injury Excerpt :

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Neuroprotective Therapy for Stroke and Ischemic Disease Book

Neuroprotective Therapy for Stroke and Ischemic Disease


  • Author : Paul A. Lapchak
  • Publisher : Springer
  • Release Date : 2017-01-12
  • Genre: Medical
  • Pages : 795
  • ISBN 10 : 9783319453453

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Neuroprotective Therapy for Stroke and Ischemic Disease Excerpt :

A critical and comprehensive look at current state-of-the-art scientific and translational research being conducted internationally, in academia and industry, to address new ways to provide effective treatment to victims of ischemic and hemorrhagic stroke and other ischemic diseases. Currently stroke can be successfully treated through the administration of a thrombolytic, but the therapeutic window is short and many patients are not able to receive treatment. Only about 30% of patients are "cured" by available treatments. In 5 sections, the proposed volume will explore historical and novel neuroprotection mechanisms and targets, new and combination therapies, as well as clinical trial design for some of the recent bench-side research.

Cellular and Molecular Approaches to Regeneration and Repair Book

Cellular and Molecular Approaches to Regeneration and Repair


  • Author : Paul A. Lapchak
  • Publisher : Springer
  • Release Date : 2017-11-17
  • Genre: Medical
  • Pages : 541
  • ISBN 10 : 3319666789

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Cellular and Molecular Approaches to Regeneration and Repair Excerpt :

This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.

Stroke Recovery and Rehabilitation  2nd Edition Book

Stroke Recovery and Rehabilitation 2nd Edition


  • Author : Richard L. Harvey, MD
  • Publisher : Demos Medical Publishing
  • Release Date : 2014-09-18
  • Genre: Medical
  • Pages : 888
  • ISBN 10 : 9781617051708

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Stroke Recovery and Rehabilitation 2nd Edition Excerpt :

The definitive core text in its field, Stroke Recovery and Rehabilitation is a comprehensive reference covering all aspects of stroke rehabilitation ó from neurophysiology of stroke through the latest treatments and interventions for functional recovery and restoration of mobility. This second edition is completely updated to reflect recent advances in scientific understanding of neural recovery and growing evidence for new clinical therapies. The second edition ó which includes free e-book access with every print purchase ó continues to provide in-depth information on the assessment and management of all acute and long-term stroke-related impairments and complications including cognitive dysfunctions, musculoskeletal pain, and psychological issues. It examines risk factors, epidemiology, prevention, and neurophysiology as well as complementary and alternative therapies, functional assessments, care systems, ethical issues, and community and psychosocial reintegration. With contributions from over 100 acknowledged leaders from every branch of the stroke recovery field, this edition features expanded coverage of key issues such as the role of robotics and virtual reality in rehabilitation. New chapters have been incorporated to cover fields of recent exploration including transcranial magnetic stimulation, biomarkers, and genetics of recovery as well as essentials like the use of medication and the survivorís perspective. The up-to-date presentation of scientific underpinnings and multi-specialty clinical perspectives from physical medicine and rehabilitation, neurology, physical therapy, occupational therapy, speech and language pathology, and nursing ensures that Stroke Recovery and Rehabilitation will continue to serve as an invaluable reference for every health care professional working to restore function and help stroke survivors achieve their maximum potential. New to Stroke Recovery and Rehabilitation, Second Edition All chapters are thoroughly revised an

Cerebral Ischemic Reperfusion Injuries  CIRI  Book

Cerebral Ischemic Reperfusion Injuries CIRI


  • Author : Weijian Jiang
  • Publisher : Springer
  • Release Date : 2018-06-29
  • Genre: Medical
  • Pages : 259
  • ISBN 10 : 9783319901947

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Cerebral Ischemic Reperfusion Injuries CIRI Excerpt :

This volume is focused on subjects related to cerebral ischemia and reperfusion injuries after acute stroke. All chapters are selected from the Sixth Elite Stroke meeting named Pangu Stroke Conference and written by members of world leading laboratories of stroke studies. The contents cover both clinical and bench studies, from basic components of cerebral arterial system to clinical reperfusion injury cases, from reperfusion caused programmed cell death and astrocyte activation to oxidative stress and nitric oxide after reperfusion, from extracellular matrix and inflammation to a role of diabetes after reperfusion, from small artery disorders to collateral circulation and blood pressure control after reperfusion. Wei-Jian Jiang, Chairman of New Era Stroke Care and Research Institute of PLA Rocket Force General Hospital, Beijing, China. Wengui Yu, Professor and Director of Comprehensive Stroke & Cerebrovascular Center, University of California, Irvine Yan Qu, Professor and Director of Neurosurgery at the Second Affiliated Hospital of Air Force Medical University, Xi’an, China. Zhongsong Shi, Professor of Neurosurgery at Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Ben-yan Luo, Professor and Chair of Neurology at the First Affiliated Hospital of Zhejiang University. John H. Zhang, Professor of Anesthesiology and Physiology at Loma Linda University School of Medicine, Loma Linda, CA, USA.