Viral Polymerases Book

Viral Polymerases

  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release Date : 2018-10-29
  • Genre: Science
  • Pages : 496
  • ISBN 10 : 9780128154236

Viral Polymerases Excerpt :

Viral Polymerases: Structures, Functions and Roles as Antiviral Drug Targets presents in-depth study information on the structure and functions of polymerases and their roles in the lifecycle of viruses, and as drug targets. Viral polymerases constitute a vital component in the lifecycle of many viruses, such as human immunodeficiency virus (HIV), hepatitis viruses, influenza virus, and several others. They are essentially required for the replication of viruses. Thus, the polymerases that can be found in viruses (called viral polymerases) represent favorable targets for the design and development of antiviral drugs. Provides comprehensive, state-of-the-art coverage on virus infections, the virus lifecycle, and mechanisms of polymerase inhibition Analyzes the structure-activity relationships of inhibitors of each viral polymerase Presents a consistent and comprehensive coverage of all aspects of viral polymerases, including structure, function and their role as antiviral drug targets

Viral Polymerases and Related Proteins Book

Viral Polymerases and Related Proteins

  • Author : Lawrence C. Kuo
  • Publisher : Elsevier
  • Release Date : 1996
  • Genre: Science
  • Pages : 658
  • ISBN 10 : 0121821765

Viral Polymerases and Related Proteins Excerpt :

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 270 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * Expression, purification, and characterization * Activity assays * Kinetic and screening * Design and analysis of substrates and inhibitors * Molecular and structural characterizations

Viral Molecular Machines Book

Viral Molecular Machines

  • Author : Michael G. Rossmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-02-02
  • Genre: Medical
  • Pages : 687
  • ISBN 10 : 9781461409809

Viral Molecular Machines Excerpt :

This book will contain a series of solicited chapters that concern with the molecular machines required by viruses to perform various essential functions of virus life cycle. The first three chapters (Introduction, Molecular Machines and Virus Architecture) introduce the reader to the best known molecular machines and to the structure of viruses. The remainder of the book will examine in detail various stages of the viral life cycle. Beginning with the viral entry into a host cell, the book takes the reader through replication of the genome, synthesis and assembly of viral structural components, genome packaging and maturation into an infectious virion. Each chapter will describe the components of the respective machine in molecular or atomic detail, genetic and biochemical analyses, and mechanism. Topics are carefully selected so that the reader is exposed to systems where there is a substantial infusion of new knowledge in recent years, which greatly elevated the fundamental mechanistic understanding of the respective molecular machine. The authors will be encouraged to simplify the detailed knowledge to basic concepts, include provocative new ideas, as well as design colorful graphics, thus making the cutting-edge information accessible to broad audience.

Human Herpesviruses Book
Score: 4
From 1 Ratings

Human Herpesviruses

  • Author : Ann Arvin
  • Publisher : Cambridge University Press
  • Release Date : 2007-08-16
  • Genre: Medical
  • Pages : null
  • ISBN 10 : 9781139461641

Human Herpesviruses Excerpt :

This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Nucleic Acid Polymerases Book

Nucleic Acid Polymerases

  • Author : Katsuhiko S. Murakami
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-22
  • Genre: Science
  • Pages : 342
  • ISBN 10 : 9783642397967

Nucleic Acid Polymerases Excerpt :

This book provides a review of the multitude of nucleic acid polymerases, including DNA and RNA polymerases from Archea, Bacteria and Eukaryota, mitochondrial and viral polymerases, and other specialized polymerases such as telomerase, template-independent terminal nucleotidyl transferase and RNA self-replication ribozyme. Although many books cover several different types of polymerases, no book so far has attempted to catalog all nucleic acid polymerases. The goal of this book is to be the top reference work for postgraduate students, postdocs, and principle investigators who study polymerases of all varieties. In other words, this book is for polymerase fans by polymerase fans. Nucleic acid polymerases play a fundamental role in genome replication, maintenance, gene expression and regulation. Throughout evolution these enzymes have been pivotal in transforming life towards RNA self-replicating systems as well as into more stable DNA genomes. These enzymes are generally extremely efficient and accurate in RNA transcription and DNA replication and share common kinetic and structural features. How catalysis can be so amazingly fast without loss of specificity is a question that has intrigued researchers for over 60 years. Certain specialized polymerases that play a critical role in cellular metabolism are used for diverse biotechnological applications and are therefore an essential tool for research.



  • Author : John J. Holland
  • Publisher : CRC PressI Llc
  • Release Date : 1988-05-31
  • Genre: Science
  • Pages : 240
  • ISBN 10 : UOM:39015012650829


Viral Replication Enzymes and their Inhibitors Part A Book

Viral Replication Enzymes and their Inhibitors Part A

  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-10-23
  • Genre: Science
  • Pages : 368
  • ISBN 10 : 9780128234693

Viral Replication Enzymes and their Inhibitors Part A Excerpt :

Viral Replication Enzymes and their Inhibitors Part A, Volume 49, the latest release in the Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of related topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series

Textbook of Influenza Book

Textbook of Influenza

  • Author : Robert G. Webster
  • Publisher : John Wiley & Sons
  • Release Date : 2014-01-06
  • Genre: Medical
  • Pages : 520
  • ISBN 10 : 9781118636831

Textbook of Influenza Excerpt :

The Textbook of Influenza is a comprehensive resourcecovering all aspects of influenza, from the genetic and molecularbiology of the virus through to clinical aspects of the disease andthe latest drug developments and treatments. This new edition hasbeen completely revised and reflects the integration of disciplinesconcerning the emergence, evolution, pathogenesis and control ofinfluenza viruses in the field of human and veterinary publichealth. Textbook of Influenza examines the lessons learnt fromthe latest pandemic and provides the current state of knowledge formany yet unresolved issues related to virus origin, spread,pathogenesis and disease severity to better prepare for futurepandemics. It covers the background to recent advances in influenzagenomics and reverse genetics which have allowed the identificationof virus virulence factors and the analysis and reconstruction ofinfluenza viruses such as the 1918 Spanish flu strain. This new edition is divided into eight key sections, containingchapters co-written by international experts from both the clinicaland scientific communities, covering: • Influenza Perspectives • Structure and Replication • Evolution and Ecology • Epidemiology and Surveillance • Immunology • Vaccines and Vaccine Development • Clinical Aspects and Antivirals • Public Health Textbook of Influenza is for all those working in thearea of influenza including clinical and basic scientists,immunologists, molecular and structural virologists, public healthofficials and global pandemic control planners.

DNA Polymerases Book

DNA Polymerases

  • Author : Anonim
  • Publisher : World Scientific
  • Release Date : 2010
  • Genre: DNA polymerases
  • Pages : null
  • ISBN 10 : 9789814465458

DNA Polymerases Excerpt :

Molecular Biology of the Cell Book
Score: 4.5
From 5 Ratings

Molecular Biology of the Cell

  • Author : Bruce Alberts
  • Publisher : Unknown
  • Release Date : 2004
  • Genre: Uncategoriezed
  • Pages : null
  • ISBN 10 : 0815332181

Molecular Biology of the Cell Excerpt :

Origin and Evolution of Viruses Book

Origin and Evolution of Viruses

  • Author : Esteban Domingo
  • Publisher : Elsevier
  • Release Date : 2008-06-23
  • Genre: Science
  • Pages : 560
  • ISBN 10 : 0080564968

Origin and Evolution of Viruses Excerpt :

New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. * NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution * UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups * SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts

Viral Proteases and Their Inhibitors Book

Viral Proteases and Their Inhibitors

  • Author : Satya Prakash Gupta
  • Publisher : Academic Press
  • Release Date : 2017-07-03
  • Genre: Science
  • Pages : 516
  • ISBN 10 : 9780128096826

Viral Proteases and Their Inhibitors Excerpt :

Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents. Provides comprehensive, state-of-the-art coverage of virus infections, the virus lifecycle, and mechanisms of protease inhibition Analyzes structure-activity relationships of inhibitors of each viral protease Presents an in-depth view of the structure and function of viral proteases

The Biology of RNA tumor Viruses Book

The Biology of RNA tumor Viruses

  • Author : Howard M. Temin
  • Publisher : Unknown
  • Release Date : 1974
  • Genre: Oncogenic viruses
  • Pages : 318
  • ISBN 10 : UOM:39015003214114

The Biology of RNA tumor Viruses Excerpt :